|
1 / 1
|
DeCS
|
|
 |
|
Descriptor English:
|
|
Complement C1s
|
|
Descriptor Spanish:
|
|
complemento C1s
|
|
Descriptor Portuguese:
|
|
Complemento C1s
|
|
Synonyms English:
|
|
C 1 Esterase
C1 Esterase
C1s Complement
C1s, Complement
Complement 1 Esterase
Complement 1s
Complement Component 1s
Complement, C1s
Component 1s, Complement
Esterase, C 1
Esterase, C1
Esterase, Complement 1
|
|
Tree Number:
|
|
D08.811.277.300.290
D12.776.124.486.274.045.290
D12.776.124.486.274.050.290
|
|
Definition English:
|
|
A 77-kDa subcomponent of complement C1, encoded by gene C1S, is a SERINE PROTEASE existing as a proenzyme (homodimer) in the intact complement C1 complex. Upon the binding of COMPLEMENT C1Q to antibodies, the activated COMPLEMENT C1R cleaves C1s into two chains, A (heavy) and B (light, the serine protease), linked by disulfide bonds yielding the active C1s. The activated C1s, in turn, cleaves COMPLEMENT C2 and COMPLEMENT C4 to form C4b2a (CLASSICAL C3 CONVERTASE). |
|
Pharmacological Action:
|
|
Immunologic Factors
|
|
History Note English:
|
|
2006 (1978)
|
|
Allowable Qualifiers English:
|
|
|
|
Record Number:
|
|
28242
|
|
Unique Identifier:
|
|
D003173
|
Occurrence in VHL:
|
|
|
Similar:
|
|
DeCS
|
|